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CBD and Breast Cancer

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Amazing what South Africans are capable of, a paper published on CBD and breast cancer. The study was completed at Nelson Mandela Bay Uni. Had the fortunate opportunity to meet this researcher a couple years ago, Amy well done for getting your first published paper out.


Endoplasmic reticulum (ER) stress is an imbalance between the protein‐folding load and capacity of ER. It can be induced by various physiological conditions, activating the unfolded protein response (UPR) to re‐establish homeostasis, promoting cell survival. Under severe or chronic stress, apoptosis is induced. Normal cells generally do not experience continuous ER stress induction. The stressful conditions experienced in the tumor microenvironment facilitate chronic ER stress and UPR activation, which plays a pivotal role in tumour survival. Exacerbation of pre‐existing ER stress can trigger cancer cell death, with a minimal effect on normal cells. Current literature suggests that cannabinoid treatment may induce cancer cell death via ER stress; however, little is known about the mechanisms of induction. Source


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